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Autoimmune polyendocrine syndrome type 2, a form of autoimmune polyendocrine syndrome also known as Schmidt's syndrome, or APS-II, is the most common form of the polyglandular failure syndromes. It is heterogeneous and has not been linked to one gene. Rather, patients are at a higher risk when they carry a particular human leukocyte antigen genotype (HLA-DQ2, HLA-DQ8 and HLA-DR4). APS-II affects women to a greater degree than men (75% of cases occur in women).〔 Features of this syndrome are: * Addison's disease * Primary hypothyroidism * Graves' disease * Pernicious anaemia * Primary hypogonadism (less common) * Diabetes mellitus (type 1) * Vitiligo (less common) * Coeliac disease * Myasthenia gravis ==Symptoms== Symptoms of Addison's disease and Hashimoto's thyroiditis include: * Dry hair * Nausea * Abdominal Pain * Frequent urination * Vomiting * Weight and muscle loss * Salt cravings / salt wasting * Anorexia and cachexia * High pulse / weakened heart * Low blood pressure * Weakness * Hypoglycemia * Numbness in extremities * Migraines / dysparunia * Poor immune system response Some researchers favour splitting this syndrome into three distinct syndromes (numbering 2, 3 and 4), but evidence for these distinct combinations is not convincing. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Autoimmune polyendocrine syndrome type 2」の詳細全文を読む スポンサード リンク
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